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What Is Lipitor ? Lipitor, known generically as atorvastatin (a Statin), is an HMG CoA reductase inhibitor. Lipitor Is Used To... .Treat primary hypercholesterolemia in those at risk for coronary artery disease. .Stop hardening of the arteries, to prevent you from heart attacks, peripheral vascular disease and stroke. Lipitor limits and stops an enzyme used by the liver in cholesterol synthesis. This lowers the amount of cholesterol produced in the body, including the LDL cholesterol. How Does It Work? Lipitor reduces the amounts of