Isotretinoin, sold under the brand name Accutane, is the only drug that can cure acne, but it can cause horrible birth defects when taken by pregnant women. Reports from Britain and Israel show that Accutane otherwise is much safer than we used to think.

Acne is a condition in which normally colorless, liquid skin oils are converted to solid white material. Then the skin responds to the trapped solid oil by turning red and swelling. A three- or four-month course of Accutane damages the oil glands and markedly reduces the amount of oil that your skin produces, making Accutane the most effective drug to treat acne. Having less skin oil should not cause any serious side effects as its only known function is to keep you from feeling too cold in the winter, because it slows evaporation of sweat. Dry skin is associated with lack of water, and aging of skin is associated with lack of collagen, not with lack of oil.

In the British study, ninety-three per cent of the people taking Accutane reported no long-term side effects. The British researchers reported that two percent suffered muscle aches at follow up, and 5 percent suffered from dry mouth. Fewer than one percent claimed that they had dry eyes and skin and joint pains. Higher doses were not associated with more side effects. The authors concluded that their study showed that isotretinoin is a safe drug with no serious long-term side-effects. However, it causes birth defects when taken during pregnancy.

A study from Israel also shows that Accutane is far safer than many doctors think. Many doctors refuse to prescribe Accutane for severe acne because they are afraid that Accutane will damage livers, raise triglyceride levels and cause heart attacks. In this study, none of the patients had liver tests that were abnormal enough to stop treatment. Only 1.5 percent of patients had serum triglyceride levels above 400 mg%, but all continued treatment. Only 3.5 percent of patients required a second treatment.

I insist that all women who take Accutane do nothing that could cause a pregnancy while they take it. Three months after stopping Accutane, a woman has no increased risk for birth defects.

I check liver tests and triglyceride levels and if normal, prescribe 40 mg of Accutane twice a day for 14 weeks. I check liver tests every four weeks and stop the drug immediately if the liver tests become abnormal. I repeat liver tests two weeks later, and if normal, restart Accutane. Eighty-two percent of those who follow this regimen are cured of acne for life. If the acne returns months or years later, I usually prescribe 40 mg of Accutane four times a day for one month. Check with your doctor.

For Journal references on Accutane see http://www.drmirkin.com/morehealth/G200.htm

Dr. Gabe Mirkin has been a radio talk show host for 25 years and practicing physician for more than 40 years; he is board certified in four specialties, including sports medicine. Read or listen to hundreds of his fitness and health reports at http://www.DrMirkin.com

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