Carpal tunnel Syndrome (CTS) is one of many musculoskeletal injuries listed under the broader terms of Repetitive Strain Injury (RSI) or Cumulative Trauma Disorder (CTD). A number of other injuries listed under these terms, but that are not exclusively caused by a repetitive strain injury or cumulative trauma disorder include Guyon's Syndrome, Tendonitis, Cubital Tunnel Syndrome, Medial and Lateral Epicondylitis and Trigger Finger.

Carpal tunnel syndrome and other repetitive strain injuries are caused by excessive overuse of a muscle or group of muscles in a unidirectional movement pattern. Examples would include typing, wringing a washcloth and using a computer mouse. All of the movement patterns involve motion against resistance in one direction