Phytopharm just completed the first phase of its five phase clinical research program and has reportedly found no complications; using hoodia is apparently safe for reasonably healthy individuals. While no hoodia side affects have been reported, it is not recommended for use by pregnant or nursing women. Consumer Reports does not recommend it for anyone, but not because of any reported side effects. They do not recommend its use, because clinical research has not been completed at this time. Complications using hoodia on a long term basis may arise. Hoodia gordonii was eaten by the San people of southern Africa, but it was not a preferred food item. They did not eat it often.

There may be complications using hoodia gordonii combined with prescription or over-the-counter medications. This has not been studied. The safest way to use hoodia gordonii supplements is under a doctor