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Phen Fen article Phen Phen is universally known by its' nickname, Phen Fen. Phen Fen is a combination of Phentermine and Fenfluramine. Phentermine decreases appetite while Fenfluramine gives the feeling of increased satiety (the quality or state of being fed or gratified to or beyond capacity). When combining the two diet drugs together, it helped overweight individuals effectively lose weight. Even though, a combination of Phentermine and Fenfluramine was never used as a combination anti-obesity drug until the early 1990s, the two drugs have been on the market separately since the 1970's. In the US, Phentermine is currently sold under the brand names Ionamin